This study was conducted to determine the low-dose effects of bisphenol A (BPA) in a rat two- generation reproduction study. Rat two- generation reproductive toxicity study of bisphenol A.Įma, M Fujii, S Furukawa, M Kiguchi, M Ikka, T Harazono, A Our results suggest that transgenerational effects differ depending on the absolute thermal change and in which life stage the thermal change is experienced. Additionally, we found that transgenerational plasticity to +1.5Â☌ induced full restoration of thermally affected reproductive and offspring attributes, which was not possible with developmental plasticity alone. Reproduction ceased at the projected future summer temperature (31.5Â☌) when fish experienced +3.0Â☌ for two generations. We found that more gradual warming over two generations, +1.5Â☌ in the first generation and then +3.0Â☌ in the second generation, resulted in greater plasticity of reproductive attributes, compared to fish that experienced the same increase in one generation. We used a model coral reef fish ( Acanthochromis polyacanthus ) to investigate the influence of thermal conditions experienced by two generations on reproductive output and the quality of offspring produced by adults. Determining the effects of higher temperatures on individual performance is made more complex by the potential for environmental conditions experienced in previous and current generations to independently affect phenotypic responses to high temperatures. Predicting the impacts of climate change to biological systems requires an understanding of the ability for species to acclimate to the projected environmental change through phenotypic plasticity. Transgenerational plasticity of reproduction depends on rate of warming across generations.ĭonelson, Jennifer M Wong, Marian Booth, David J Munday, Philip L However, in response to exposure to alarm pheromone, aphids with Hamiltonella defensa or Serratia symbiotica symbiotic infections increased reproduction but those Aphids with different species of facultative symbiotic bacteria had different reproductive patterns overall, but symbionts in general did not alter aphid reproduction in response to bacterial exposure. Results We found that aphids stabbed abdominally with a sterile needle had reduced fecundity relative to control aphids but that aphids stabbed with a needle bearing heat-killed bacteria had reproduction intermediate, and statistically indistinguishable, to the aphids stabbed with a sterile needle and the controls. For each challenge, we also examined whether the presence of symbionts modified the host response, as maintaining host fitness in the face of challenge would benefit both the host and its dependent bacteria. As a comparison to the response to the internal cue of risk elicited by immunological challenge, we also exposed pea aphids to an external cue of risk - the aphid alarm pheromone (E)-β-farnesene (EBF), which is released in the presence of predators. Here we examined whether pea aphids (Acyrthosiphon pisum) respond to immunological challenges by increasing reproduction. Such a response would reduce the need to mount a potentially energetically costly immune response, and would parallel that of other hosts that alter life-history traits when there is a risk of infection. An alternative, non-immunological response that may be available to infected aphids is to increase reproduction, thereby ameliorating fitness loss from infection. Perhaps as a result of this bacterial dependence, aphids have limited immune function that may leave them vulnerable to bacterial pathogens. the risk for TNBC (OR = 0.78, CI 0.70-0.88, p diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.Īphid reproductive investment in response to mortality risksīackground Aphids are striking in their prodigious reproductive capacity and reliance on microbial endosymbionts, which provision their hosts with necessary amino acids and provide protection against parasites and heat stress. pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. Reproductive profiles and risk of breast cancer subtypesīrouckaert, Olivier Rudolph, Anja Laenen, Annouschkaīackground: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes.
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The idea that he'd risk all of his progress towards that revenge for the increase in profits Walt offers is difficult to believe.Ģ) Why does Mike keep working for Gus? He clearly wants to support his family, but it seems like he'd have saved up quiet a bit for them. Gus on Better Call Saul has a shitload of money already, and seems to build the Superlab more as a goal to get revenge on the cartel than for financial gain. The Gus we know on BCS has no reason to hire Walt when it so strongly jeopardizes his revenge plan. I'm sure this will change as we head into the final few episodes and Jimmy moves out of this kind of fence-sitting situation, and Mike will be put into some kind of situation where he is tested.Īs far as Mike's side of the show goes, there's two big questions I kinda have about how we get from Better Call Saul to Breaking Bad at the moment:ġ) Why does Gus hire Walt? He seems to care only about revenge on Hector. So, on both sides of the show you are in these kind of non-critical stages. Will something push him to stop caring, or does he already not care and we just haven't seen it yet? That's kind of the question with him right now. Mike still has further to go in terms of becoming the person we know from breaking bad - he was far colder about doing violence, the Mike we've seen on BCS so far hasn't really done any violence yet. Gus and Mike are putting something together, but there isn't much in terms of action or character progression happening here right now. We haven't seen him kill anyone for Gus, or be put into a dangerous situation, so things are just kind of going along smoothly. Mike's progression into his criminal life is further advanced - he's now working for Gus and so his transition into that world is relatively complete. I'm enjoying the season but I can't deny there's a bit of a meandering feeling about it. How satisfying this is to watch as it unfolds I suppose is up for debate. It is how they are choosing to express his progression - rather than having a 'moment', his descent into criminality and sleaze is happening with all these little cuts and scratches. He does something Saulish, then doubles back, then goes forward again. It's not surprising there is some discontent about what is essentially two steps forward one step back type storytelling with Jimmy. Now he's gone, we're moving towards the next phase of Jimmy's life - but we're not there. Chuck kind of was the glue for S1-3, at least for Jimmy's storyline and the other characters on that side of the show. The thing with the show just now is, this is a transitional period for pretty much all of the characters. Attack enemy’s convoys, defend satellites through intense aerial dogfights, protect surrounded recon squads using a powerful gunship and much more to win the War. 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If you are interested in buying Mosaic District real estate in Virginia, please contact us today. The quaint homes for sale in the Mosaic District add to the overall atmosphere of the community. Buyers can find a home for sale in the Mosaic District that suits their needs and presents them with between 600-1,500 square feet of living space. Living in the Mosaic District means rubbing elbows with quality people, staying up to date on the latest trends, and catching a flick at the prominent Angelika Film Center.Ĭondos for sale in the Mosaic District can be found with one- and two-bedroom floor plans. In an isolated home in the countryside, dreams lie in tatters, hopes are dashed, and hearts broken. An actress wants to fight the changing of the times. A successful writer longs for a sense of achievement. Retail District Manager Cannabis The Green Organic Dutchman Mosaic is a leading North American Integrated Agency, specialized in connecting with consumers through Experiential Marketing. 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Stay up to date on the Mosaic District market See Homes for Sale in Mosaic District on a Map 27, according to its Instagram.īASH didn’t return FFXnow’s requests for comment.See ALL the Homes for Sale in Mosaic District 23 and will have an opening party event on Oct. The Arlington-based company officially opened the doors of its newest gym on Sept. In other Mosaic District developments, BASH Boxing is now open at 2905 District Ave, Suite 195. However, a Shopify store called Book Girl Bakes appears to be coming soon. “While the shop won’t be open anymore, there are still cookies to be baked! If you would like to reach out and learn about what we are doing next, email or ,” the letter said.įFXnow attempted to contact Praline by email and phone but hasn’t heard back, as of press time. With boutique hotel-style hospitality, you and your team are going to. Our members include entrepreneurs, established businesses, startups, and small- to medium-sized businesses. 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See the man page of setpriority().ĭb_1 | T21:52:06.675930Z 0 InnoDB: Highest supported file format is Barracuda.ĭb_1 | T21:52:06.691499Z 0 InnoDB: Creating shared tablespace for temporary tablesĭb_1 | T21:52:06.691700Z 0 InnoDB: Setting file './ibtmp1' size to 12 MB. Please use -explicit_defaults_for_timestamp server option (see documentation for more details).ĭb_1 | T21:52:06.640167Z 0 mysqld (mysqld 5.7.29) starting as process 1. Localhost:maps davea$ docker-compose up -force-recreateĭb_1 | 21:52:06+00:00 : Entrypoint script for MySQL Server 5.7.29-1debian9 started.ĭb_1 | 21:52:06+00:00 : Switching to dedicated user 'mysql'ĭb_1 | T21:52:06.638642Z 0 TIMESTAMP with implicit DEFAULT value is deprecated. localhost:maps davea$ docker-compose build However, when I attempt to run my image, it still appears the database is listening on the old port, 3306. # So you don't have to use root, but you can if you like I want to build a docker image that houses a MySql 5.7 database, but I would like to change the default port on which MySql listens to 3406. Assignors: Movandi Corporation Assigned to SILICON VALLEY BANK, AS AGENT reassignment SILICON VALLEY BANK, AS AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: Boers, Michael, GHARAVI, SAM, SHIRINFAR, FARID, BESOLI, ALFRED GRAU, ROFOUGARAN, AHMADREZA, ROFOUGARAN, MARYAM, YOON, SEUNGHWAN Publication of US20180115087A1 publication Critical patent/US20180115087A1/en Application granted granted Critical Publication of US10135153B2 publication Critical patent/US10135153B2/en Assigned to SILICON VALLEY BANK reassignment SILICON VALLEY BANK SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by Movandi Corp filed Critical Movandi Corp Priority to US15/335,179 priority Critical patent/US10135153B2/en Assigned to Movandi Corporation reassignment Movandi Corporation ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Original Assignee Movandi Corp Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) ( en Inventor Alfred Grau Besoli Seunghwan Yoon Ahmadreza Rofougaran Farid SHIRINFAR Sam Gharavi Michael BOERS Maryam Rofougaran Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number US15/335,179 Other versions US10135153B2 Google Patents US20180115087A1 - Phased Array Antenna Panel with Configurable Slanted Antenna Rows US20180115087A1 - Phased Array Antenna Panel with Configurable Slanted Antenna Rows BLOCK WORLD PROBLEM USING PROLOG HOW TO.(i) Apply Program 14.11 to solve another simple blocks world prob- lem. Program 14.12 Testing the depth-first planner Testing and data test-plan (Name, Plan) initial_state (Name,I), final state (Name,F), transform(I,F,Plan). suggest(to_block(X,Y,Z), State) member(on(X,Z),State), block(2). suggest (to-place(X,Y,Z), State) member(on(X,Z),State), place(2). choose_action(Action, State1, State2) legal_action(Action, Statel). A sim- ple definition suffices to produce intelligent behavior in our example problem: choose_action(Action, Statei, State2) - suggest (Action, State2), legal_action(Action, Statel). The predicate legal action can be re- placed by a predicate choose_action(Action, State1, State2). It is easy to incorporate a little more intelligence by first trying to achieve one of the goal states. After that, block b is moved to q, block a is moved to p and b, and after 20 more random moves, the final configuration is reached. The first plan it produces is horrendous, however: Program 14.11 successfully solves the simple problem given as Pro- gram 14.12. For each, the conditions for which it is legal must be specified, and a method given for updating the state as a result of performing the action. There are two possible actions, moving to a block and moving to a place. Program 14.11 A depth-first planner The nondeterministic algorithm used by the planner is given by the recursive clause of transform/4 in the program: While the desired state is not reached, find a legal action, update the current state, check that it has not been visited before. substitute (X,Y,Xs, Ys) - See Exercise 3.3(i). update(to-place(X,Y,Z), State, Statel) substitute (on (X,Y),on(X,2), State, Statel). update(to_block(X,Y,Z),State, Statel) substitute (on(X,Y),on(X,Z),State, Statel). clear (X,State) - not member(on(A,X), State). legal_action(to_block(Block1,Y,Block), State) on (Block1, y, State), clear(Block1, State), block (Block2), Block1 # Block2, clear(Block2, State). legal_action(to-place (Block,Y,Place), State) - on(Block, Y, State), clear (Block, State), place(Place), clear (Place, State). transform(State1, State2, Visited, ) - legal_action(Action, Statel), update (Action, State1, State), not member (State, Visited), transform(State, State2, [State|Visited), Actions). transform (State1, State2,Plan) - transform(State1, State2, ,Plan). Transform(State1, State2,Plan) Plan is a plan of actions to transform Statel into State2. The predicates clear/2 and on/3 in Pro- gram 14.11 take advantage of this representation. The state descriptions allow easy testing of whether a block or place X is clear in a given state by checking that there is no relation of the form on (A,X). The state descriptions are ordered in the sense that the on relation for a precedes that of b, which precedes the on relation for c. For example, the initial and final states in Figure 14.4 are, respectively, and [on(a,b),on(b, c),on(c,r)). They represent the facts that are true in the state. States are represented by a list of relations of the form on (X,Y), where X is a block and Y is a block or place. A plan of actions, Plan, is produced that transforms State1 into State2 when executed. The top-level procedure of Program 14.11 solving the problem is transform (Statei, State2,Plan). For an action to succeed, the top of the moved block must be clear, and also the place or block to which it is being moved must be clear. The actions allowed are moving a block from the top of a block to a place and moving a block from one block to another. There are three blocks, a, b, and c, and three places, p, q, and r. Figure 14.4 gives the initial state and the desired final state of a blocks world problem. The problem is to form a plan in the blocks world, that is, to specify a sequence of actions for restacking blocks to achieve a particular con- figuration. It combines the two extensions mentioned before – keeping an accumulator of what has been traversed, and computing a path. The program is written nondeterministically, essen- tially performing a depth-first search. This section is completed with a program for building simple plans in the blocks world. This is discussed further in Section 16.2. To do so, breadth-first search is necessary. Transcribed image text: a a b с b р a r р q Figure 14.4 Initial and final states of a blocks world problem The program is not guaranteed to reach every node of an infinite graph. |
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